蛋白C受体是一组不同乳腺癌中的治疗干细胞靶点

乳腺癌是一种异质性疾病。特别是，三阴性乳腺癌(TNBC)包括各种身份不明的分子亚组，目前几乎没有靶向治疗选择。我们之前的研究发现蛋白质C受体（生殖)作为位于正常乳腺基底层的乳腺干细胞(MaSCs)的表面标记。鉴于TNBC与基层干细胞的可能联系，我们对生殖小鼠和人类乳腺癌。在小鼠乳腺肿瘤中，我们发现生殖细胞+细胞富含肿瘤干细胞Wnt1基底样肿瘤，但不在Brca1基底样肿瘤或PyVT内腔肿瘤。在人类癌症中，PROCR在一半的TNBC病例中得到强有力的表达。用病人来源的异种移植物(PDXs)进行的实验表明，PROR标记了这个离散亚组(称为PROR)中的干细胞+TNBC)。用抑制性纳米体干扰生殖细胞的功能可减少肿瘤干细胞数量，抑制肿瘤生长，防止肿瘤快速复发。我们的数据表明MaSC在乳腺肿瘤发生中起着关键作用。此外，我们的工作表明，生殖细胞可用作生物标志物，将TNBC分为临床相关亚组，并可能为这一临床重要肿瘤亚型提供新的靶向治疗策略。

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